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专利名称：METHODS DEVICES AND SYSTEMS OF
PREPARING TARGETED MICROBUBBLESHELLS
发明人：Mark A. Borden,Cherry Chen申请号：US13695677申请日：20110430
公开号：US20130101521A1公开日：20130425
专利附图：
摘要：Targeted microbubbles are generated by post-labeling buried ligand
microbubbles. According to embodiments, buried ligand microbubbles are created with
steric brushes protecting functionalized polymer tethers. Ligands were attached to thefunctionalized tethers by diffusion of ligands of a small size through the steric barrier.The steric barrier was substantially capable of hindering access to the tethers by largermolecules. The embodiments disclosed include methods for creating microbubblebatches that can be loaded with selected ligands, for titrating the targeting ligandsthereby to reduce waste and cost, and for using resulting buried ligand molecules formedical purposes.
申请人：Mark A. Borden,Cherry Chen
地址：Boulder CO US,New York NY US
国籍：US,US
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