专利内容由知识产权出版社提供
专利名称：Stabilised fibrate microparticles发明人：GARY PACE,ROBERT A. SNOW,POL-HENRI
GUIVARC'H
申请号：AU2007201953申请日：20070501公开号：AU2007201953B2公开日：20090813
摘要：This invention discloses an orally administered pharmaceutical compositioncomprising microparticles of solid fenofibrate that are stabilized by a phospholipidsurface active substance that is present during the preparation of the microparticles,wherein a therapeutically effective amount of the composition provides a quantity offenofibrate active species to a fasted human patient in need of treatment by fenofibratethat is greater than 80 % of the quantity of fenofibrate active species provided by thesame amount of the composition when administered to the same patient who has beenfed a high fat meal consisting of at least 1000 calories, 50 % of which are from fat. Thepresent invention also provides a method of treatment of dislipidemia and
dislipoproteinemia in a mammal consisting of administering a therapeutically effectiveoral dosage form comprising microparticles of a solid fibrate that are stabilized by aphospholipid surface active substance wherein the dosage form provides into the bloodof the patient in a fasted state a therapeutically effective amount of a fibrate activespecies that is at least 90 % of the AUC amount of the fibrate active species provided bythe same dosage form into the blood of the same patient when the patient is in a fedstate.
申请人：SKYEPHARMA CANADA, INC.
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