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专利名称：Chemiluminescent influenza diagnostic kit发明人：Craig D. Shimasaki,Komandoor Elayavalli
Achyuthan,Brooks Edwards
申请号：US10691017申请日：20031022公开号：US07081352B2公开日：20060725
摘要：A chemiluminescent system for detecting the presence of influenza virus in abiological fluid sample is provided. An influenza diagnostic kit is provided which includes(1) a sampling device for obtaining the biological fluid from a subject, (2) a
chemiluminescent substrate material which, in the presence of influenza virus in thebiological sample, will generate a chemiluminescent product that will produce detectablelight, and (3) a means for detecting any generated light. A liquid sample containing thebiological fluid, and preferably a diluent, are contacted with the an absorbent materialcontaining the chemiluminescent substrate material. The substrate responds toneuraminidase activity intrinsic to influenza A and influenza B virus particles, such thatwhen the substrate is in contact with influenza virus, the substrate is cleaved to yield achemiluminescent product that then decomposes to produce light which can then bedetected. The chemiluminescent substrate materials include enzymatically triggerable1,2-dioxetane derivatives of 4-alkoxy-N-acetylneuraminic acid and 4,7-dialkoxy-N-acetyineuraminic acid. The system is sufficiently simple that it can reliably be used by alayperson in a nonmedical setting. The biological fluid generally originates from the oralcavity, the pharyngeal cavity, or the nasopharyngeal cavity.
申请人：Craig D. Shimasaki,Komandoor Elayavalli Achyuthan,Brooks Edwards
地址：Edmond OK US,Oklahoma City OK US,Cambridge MA US
国籍：US,US,US
代理机构：Fitch, Even, Tabin & Flannery
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