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专利名称：NUCLEIC ACID ARRAY COMPRISING
SELECTIVE MONOCYTIC MACROPHAGICGENES
发明人：STUHLMUELLER, BRUNO,HAEUPL,
THOMAS,KIESSLICH, OLAF,BURMESTER,GERD-RUEDIGER
申请号：EP03740060.3申请日：20030528公开号：EP1523575A1公开日：20050420
摘要：The invention relates to an array comprising oligo- or poly-nucleotide probes,immobilised on a solid support. The array is characterised in that, sequences of aselection or all of the selective monocytic macrophagic genes given in tables 1 6 arebonded on the surface. The array permits the diagnosis of rheumatoid arthritis and otherchronic inflammatory diseases, a corresponding analysis of the efficacy of treatment andthe monitoring of side-effects with the anti-tumor necrosis factor (TNF) therapy and thuspermits the selection of the most effective therapy for each patient with rheumatoidarthritis. The invention further relates to a nucleic acid array for the prognosis anddevelopment of novel anti-TNF type medicaments and such medicaments with a mode ofaction in said regulatory circuit.
申请人：OLIGENE GMBH
地址：Schumannstrasse 20/21 10117 Berlin DE
国籍：DE
代理机构：Engelhard, Markus
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