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专利名称：3-(Hydroxy or hydroxymethyl)-6-methyl-5-(4-pyridinyl)-2(1H)- pyridinone andcardiotonic use thereof
发明人：George Y. Lesher,Richard E. Philion申请号：US06/296291申请日：19810826公开号：US04361569A公开日：19821130
摘要：3-(Hydroxy or hydroxymethyl)-6-methyl-5-(4-pyridinyl)-2(1H)- pyridinone orpharmaceutically acceptable acid-addition salt thereof is useful as a cardiotonic agent. 3-Hydroxy-6-methyl-5-(4-pyridinyl)-2(1H)- pyridinone is prepared by autoclaving a mixtureof a sodium or potassium lower-alkoxide, a lower-alkanol and 3-(chloro or bromo)-6-methyl-5-(4- pyridinyl)-2(1H)- pyridinone and acidifying the reaction mixture. 3-Hydroxymethyl-6-methyl- 5-(4-pyridinyl)-2(1H)-pyridinone is prepared by reacting 6-methyl-5-(4- pyridinyl)-2(1H)-pyridinone with excess formaldehyde at an acidic pH. Said 3-(hydroxy or hydroxymethyl)-6-methyl- 5-(4-pyridinyl)-2(1H)- pyridinone orpharmaceutically acceptable acid- addition salt thereof is disclosed as the activeingredient in cardiotonic compositions for increasing cardiac contractility and in themethod for increasing cardiac contractility in a patient requiring such treatment.
申请人：STERLING DRUG INC.
代理人：Robert K. Bair,B. Woodrow Wyatt,Paul E. Dupont
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