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专利名称：Combinatorial libraries of proteins having
the scaffold structure of C-type lectin-likedomains
发明人：Michael Etzerodt,Thor Las Holtet,Niels
Jonas Heilskov Graversen,Hans ChristianThøgersen
申请号：US11633040申请日：20061204公开号：US08017559B2公开日：20110913
摘要：The present invention provides novel polypeptides having the scaffoldstructure of a C-type lectin-like domain (CTLD) and a randomized loop region forspecifically binding a variety of target compounds and also provides nucleic acidsencoding the polypeptides. The present invention further provides combinatorial CTLDlibraries, methods for constructing the libraries, and methods for screening the librariesto identify and isolate the novel CTLD polypeptides. Specifically, the invention provideslibraries of nucleic acids encoding polypeptides having a scaffold CTLD with a randomizedloop region, as well as nucleic acid sequences, vectors, and methods for preparing andexpressing the libraries. Exemplary nucleic acids useful in the combinatorial libraries arederived from tetranectin and other proteins having a CTLD.
申请人：Michael Etzerodt,Thor Las Holtet,Niels Jonas Heilskov Graversen,HansChristian Thøgersen
地址：Hinnerup DK,Rønde DK,Åbyhøj DK,Mundelstrup DK
国籍：DK,DK,DK,DK
代理机构：McDonnell Boehnen Hulbert & Berghoff LLP
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