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专利名称：Encapsulating particles with coatings that
conform to size and shape of the particles
发明人：Itai Cohen,Sidney Nagel,Horacio Rilo,Milan
Mrksich
申请号：US09575844申请日：20000518公开号：US06558665B1公开日：20030506
摘要：Particles such as islet cells are encapsulated by a method that forms a coatingof uniform thickness that conforms to the size and shape of the particles. Two
substantially immiscible liquids of different densities are provided in a container as upperand lower liquids such that an interface exists between the liquids. The upper liquid is lessdense and has a greater viscosity than the lower liquid which is a coating liquid containingparticles to be encapsulated. A tube is positioned in the upper liquid such that an orificeof the tube is above the interface. A pump connected to the tube sucks liquid throughthe tube at a rate sufficient to form a spout containing substantially the lower liquidextending between the interface and the tube orifice. The spout has maximum diameterat the interface and decreases in diameter as the spout approaches the tube orifice.Particles in the lower liquid are drawn up through the spout as liquid is withdrawn, andcoated particles are released from the spout at a point where the diameter of the spoutis less than the diameter of the particles, and the coated particles flow through the tube.The coating liquid may be a pre-polymer that can be polymerized and crosslinked aftercoating. The coated particles have therapeutic applications such as administering coated
islet cells to treat diabetes.
申请人：ARCH DEVELOPMENT CORPORATION
代理机构：Brinks Hofer Gilson & Lione
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