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专利名称：COMPOSITION AND METHOD FOR
INTRODUCTION OF RNA INTERFERENCESEQUENCES INTO TARGETED CELLS ANDTISSUES
发明人：Michael R. Simon申请号：US12917365申请日：20101101
公开号：US20110110937A1公开日：20110512
摘要：A composition and method are provided by which double-stranded RNAcontaining small interfering RNA nucleotide sequences is introduced into specific cellsand tissues for the purpose of inhibiting gene expression and protein production in thosecells and tissues. Intracellular introduction of the small interfering RNA nucleotidesequences is accomplished by the internalization of a target cell specific ligand bondedto a RNA binding protein to which a double-stranded RNA containing a small interferingRNA nucleotide sequence is adsorbed. The ligand is specific to a unique target cellsurface antigen. The ligand is internalized after binding to the cell surface antigen or bythe incorporation of a peptide into the structure of the ligand or RNA binding protein orattachment of such a peptide to the ligand or RNA binding protein. The composition andmethod are practiced in whole living mammals, as well as cells living in tissue culture.
申请人：Michael R. Simon
地址：Ann Arbor MI US
国籍：US
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